Our
people
Professor Colin Fishwick
Title
Professor of Medicinal Chemistry
c.w.g.fishwick@leeds.ac.uk
Phone
0113 3436510
Address
University of Leeds
School of Chemistry
Leeds
LS2 9JT
BHRC Role
- STRF Lead
- Director of the MCCB Technology Group
Research Interests
- Structure based drug design
- Synthetic Methods
- Medicinal chemistry
- Chemical biology
- Molecular Modelling
About
Upon completion of Colin’s doctorate in synthetic organic chemistry at the University of Liverpool in 1985 he joined the faculty at University of Leeds, School of Chemistry where he is currently Reader in Organic chemistry and Director of the Medicinal Chemistry and Chemical Biology (MCCB) technology support group of the BHRC.
His research has focused on a number of areas including the development of new synthetic reactions with particular emphasis, in recent years, on the synthesis of biologically active molecules and on the study and application of molecular self-assembly. Additionally, in recent years, he has published key findings on the application of computer-aided molecular design to the production of sub-micromolar inhibitors of bacterial and malarial enzymes and human receptors respectively. In collaboration with various groups both nationally and internationally, he is presently using computational and synthetic techniques to produce small-molecule inhibitors for use in the treatment of both infective- and non-infective diseases, respectively. Within the infective diseases area, systems presently under study include a range of enzymes derived from pathogens including those involved in bacterial cell-wall biosynthesis, and in the biosynthesis of nucleic acids from malarial parasites. Research on the production of inhibitors of enzymes associated with non-infective diseases includes work on the development of new anti-thrombotics, and new anti-cancer compounds.
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