Our
people
Dr Stacy-Paul Wilshaw
Title
Senior Translation Research Fellow – Vascular Tissue EngineeringPhone
0113 34(35651)Address
Institute of Molecular and Cellular Biology
Garstang Building
Faculty of Biological Sciences
University of Leeds
Leeds
LS2 9JT
Research Interests
- Regenerative medicine/ Tissue Engineering
- Biocompatibility of acellular tissues
- Immune response towards biomaterials
- Thrombogenicity of acellular arteries
- Development of in vitro models of native and diseased arteries
- Development of long term physiological bioreactor systems
- Non invasive imaging modalities
- Non destructive cell viability determination
- Tissue characterisation
- Angiogenesis
- Long term organ culture
- Self assembling peptides
About
Both my first degree and my PhD were from the University of Leeds. I graduated in 2002 with a BSc in Microbiology with Immunology followed by a PhD in Tissue Engineering within the Institute of Medical and Biological Engineering.
My PhD research involved testing the hypothesis that an acellular human amniotic membrane could be developed that was non-immunogenic, semi transparent, biocompatible and capable of supporting allogeneic epithelial cells for ophthalmic applications.
Following my PhD I remained within the iMBE investigating the anti adhesive mechanisms for Permacol, a commercially available acellular surgical patch. I have was also determining the immunogenicity of a number of novel self assembling peptides in vitro and using an in vivo model system.
In 2007 I began a project in collaboration with tissue Regenix Group plc and NHS BT Tissue Services looking at the development of clinically relevant acellular small and large diameter arteries. The work has led to the production of a number of acellular arteries from allogeneic and xenogenic sources.
Now, as a BHRC STRF, I am focusing on the clinical translation of small diameter vascular grafts to clinical use. We are investigating the interaction of acellular porcine and human vessels with blood and the immune system.
New work will include the implementation of novel sterilisation techniques and the screening of novel compounds to reduce thrombogencity of small diameter blood vessels.
I am also investigating the development of in vitro model systems for native and diseased arteries as well as sstrategies for vascularisation of dense tissues/ organs and production of micro vascular networks.
http://www.imbe.leeds.ac.uk/cgi-bin/sis/eng/ext/staff_pub.cgi/bmb9spw.html?defunit=IMBE
http://www.cardiovascular.leeds.ac.uk/staff/Wilshaw_S/
Collaboration
Tissue Regenix Group Plc
NHS Blood and Transplant Tissue Services
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