Group Capabilities

The MCCB group has core capabilities in a number of areas for which bioactive molecules may be identified and optimised as therapeutics or deployed as tools to understand biological mechanism:

Medicinal chemistry

• Hit identification
• Hit-to-lead

Chemical Biology

• Chemical diagnostics and probes
• Imaging agents
• Affinity chromatography

Computational chemistry and virtual drug design

• Ligand-and structure-based design
• Virtual screening
• De novo design
• Physicochemical and ADME property prediction
• Novel protein-protein inhibitor virtual libraries

High-throughput screening

• 20k member diverse lead-like library, including novel scaffolds based on diversity orientated synthesis
• Assay transfer
• Liquid handling robotics
• Data gathering and analysis

Targeted capabilities

• Modulators of protein-protein interactions