Case Studies

The MCCB group is working with a number of research groups from the University of Leeds to identify and optimise small molecule modulators of novel biological targets from a number of target classes and therapeutic areas, including oncology, cardiology and rheumatology. We are also working with a number of groups to design bioactive molecules as tools to understand biological mechanisms, including the design of targeted contrast imaging agents for MRI and targeted ligands for affinity chromatography.

We are always interested in initiating new collaborations with research groups who share common and complementary interests.

Examples of current projects:

Identification and optimisation of small molecules inhibitors as treatment for thrombosis [Philippou, Ariens, Fishwick]

Identification of small molecule modulators of hepatitis C virus (HCV) p7 protein [Griffin, Harris]

Development and application of electrochemical microarrays for detection of small molecule–protein interactions [Johnson, Bon]

Design and synthesis of novel small molecule modulators of a protein-protein interaction targeting lipoprotein reduction [Hooper, Kearney, Fishwick]